Yu-Chun LinPersonal data of - 國立清華大學生命科學院分子醫學研究所

Faculty & Staff

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Name	Yu-Chun Lin
Personal website	http://yuchunlab.wix.com/ycllab-at-nthu
Reference website of individual publication	Please click here
Reference website of individual research	Please click here

Category	Full-Time
Title	Associate Professor
Administrative Affairs	Institute of Molecular Medicine / Interdisciplinary Program of Life Science / Department of Medical Science
Discipline	Cell Biology/Molecular Biology/Biotechnology
Research expertise	Cell Biology/Molecular Biology/Cell imaging/Biotechnology
Forum	Forum link
Laboratory	Fundamental Life Science Experiments /

Recent Publications
Year	Publication	Author
2021	2021,Yang WT, Hong SR, He K, Ling K, Shaiv K, Hu J#, Lin YC#. (2021) "The emerging roles of axonemal glutamylation in regulation of cilia architecture and functions" Frontiers in Cell and Developmental Biology. 9:622302,Frontiers in Cell and Developmental Biology*,9,622302, (SCI)	Yu-Chun Lin
2021	2021,Hsu TW, Lu YJ, Lin YJ, Huang YT, Hsieh LH, Wu BH, Lin YC, Chen LC, Wang HW, Chuang JC, Fan YQ, Haung CC#. (2021) Biomaterials "Transplantation of 3D MSC/HUVEC spheroids with neuroprotective and proangiogeneic potentials ameliorates ischemic stroke brain injury". (Accepted), (SCI)	Yu-Chun Lin
2020	2020,Huang YS, Fan CH, Yang WT*, Yeh CK#, Lin YC#. (2020). “Sonogenetic modulation of cellular activities in mammalian cells”. Methods in Molecular Biology (in press),	Yu-Chun Lin
2020	2020, (SCI)	Yu-Chun Lin
2020	2020, (SCI)	Yu-Chun Lin
2020	2020,Wu CY, Fan CH, Chiu NH, Lin YC#, Yeh CK#. (2020) "Targeted delivery of engineered auditory sensing protein for ultrasound neuromodulation in the brain". Theranostics. Accepted, (SCI)	Yu-Chun Lin
2020	2019,Huang YS, Fan CH, Hsu N, Chiu NH, Wu CY, Chang CY, Wu BH, Hong SR, Chang YC, Wu AYT, Guo V, Chiang YC, Hsu WC, Chen L, Lai CPK, Yeh CK, Lin YC Sonogenetic modulation of cellular activities using an engineered auditory-sensing protein. Nano Letters, Accepted., (SCI)	Yu-Chun Lin
2018	2018,Hong, S.R., Wang, C.L., Huang, Y.S., Chang, Y.C., Chang, Y.C., Pusapati, G.V., Lin, C.Y., Hsu, N., Cheng, H.C., Chiang, Y.C., Huang, W.E., Shaner, N.C., Rohatgi, R., Inoue T.,* Lin, Y.C.* Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Nature Communications (Accepted), (SCI)	Yu-Chun Lin
2018	2018, (SCI)	Yu-Chun Lin
2017	2017,Ching-Hsiang Fan, Yao-Shen Huang, Wei-En Huang, Albert Alexander Lee, Sheng-Yang Ho, Yu-Lin Kao, Cuei-Ling Wang, Yen-Ling Lian, Tasuku Ueno, Tsung-Shing Andrew Wang, Chih-Kuang Yeh, Yu-Chun Lin. "Manipulating cellular activities using an ultrasound-chemical hybrid tool". ACS Synthetic Biology. ( Corresponding author) (Accepted), (SCI)	Yu-Chun Lin
2017	2017, (SCI)	Yu-Chun Lin
2016	2016,106,pp46-57 (SCI)	Yu-Chun Lin
2015	Phua, S.C., Lin, Y.C., Inoue, T. (2015). Cell Calcium (in press). “Primary cilium harnesses TRP channels to decode polymodal stimuli”, (SCI)	Yu-Chun Lin
2014	Kobayashi, T., Kim, S., Lin, Y.C., Inoue, T., Dynlacht, B.D. (2014). Journal of Cell Biology 204(2):215-229. “CP110-interacting proteins, Talpid3 and Cep290, play overlapping and distinct roles in cilia assembly”, (SCI)	Yu-Chun Lin
2013	Lin, Y.C., Nihongaki, Y., Liu, T.Y., Razavi, S., Sato, M., Inoue, T. (2013). Angewande Chemie International Edition 52(25): 6450-6454. “Rapidly reversible manipulation of molecular activity with dual chemical dimerizers”, (SCI)	Yu-Chun Lin
2013	Lin, Y.C., Niewiadomski, P., Lin, B., Nakamura, H.*, Phua, S.C., Jiao, J., Levchenko, A., Inoue, T., Rohatgi, R., Inoue, T. (2013). Nature Chemical Biology 9(7):437-443. “Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier”,	Yu-Chun Lin
2013	Thevathasan, J.V., Tan, E., Zheng, H., Lin, Y.C., Li, Y., Inoue, T., Fivaz, M. (2013). Mol Biol Cell 24(14):2228-2237. “The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblasts”, (SCI)	Yu-Chun Lin
2013	Lin, Y.C.,* Phua, S.C., Lin, B., Inoue, T*. (2013). Current Opinion in Chemical Biology 17(4):663-671. “Visualizing molecular diffusion through passive permeability barriers in cells: conventional and novel approaches”, (SCI)	Yu-Chun Lin
2011	Kuo, C.Y., Lin, Y.C., Yang, J.J., Yang, V.C. (2011). Biochemical and Biophysical Research Communications 414,337-343. “Interaction abolishment between mutant caveolin-1(Δ62-100) and ABCA1 reduces HDL-mediated cholesterol efflux”, (SCI)	Yu-Chun Lin
2011	Lin, Y.C., Chiang, T.C., Liu, Y.C., Tsao, Y.C., Lee, F.J. (2011). Journal of Cell Science 124, 4014-4026. “ARL4A acts with GCC185 to modulate Golgi complex organization”, (SCI)	Yu-Chun Lin
2010	Ho, H.C., Lin, Y.C., Kao, C.T., Ting, C.T., Lin, W.W., Yang, V.C. (2010) Tunghai Science 12,1-14. “Delivery of caveolin-1 gene into arterial walls of rabbits via an infiltrator angioplasty balloon catheter”,	Yu-Chun Lin
2009	Lin, Y.C., Lin, C.H., Yang, V.C. (2009). Biochemical and Biophysical Research Communications 382,189-195. “ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells”, (SCI)	Yu-Chun Lin
2007	Lin, Y.C., Ma, C., Hsu, W.C., Lo, H.F., and Yang, V.C. (2007). Cardiovascular Research 75, 575-583. “Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells”, (SCI)	Yu-Chun Lin
2006	Lin, W.W., Lin, Y.C., Chang, T.Y., Tsai, S.H., Ho, H.C., Chen, Y.T., and Yang, V.C. (2006). Journal of Histochemistry & Cytochemistry 54, 897-904. “Caveolin-1 expression is associated with plaque formation in hypercholesterolemic rabbits”, (SCI)	Yu-Chun Lin
2005	Chao, W.T., Tsai, S.H., Lin, Y.C., Lin, W.W., and Yang, V.C. (2005). Biochemical and Biophysical Research Communications 332,743-749. “Cellular localization and interaction of ABCA1 and caveolin-1 in aortic endothelial cells after HDL incubation”, (SCI)	Yu-Chun Lin

Seminar paper summary
Year	Conference period	Publication	Author
2016	2016/11/01 2016/11/01	2017,2016/11/01	Yu-Chun Lin
2016	2016/09/01 2016/09/01	2016,2016/09/01	Yu-Chun Lin
2016	2016/09/01 2016/09/01	2016,2016/09/01	Yu-Chun Lin
2015	2015/10/16 2015/10/17	2015,Emily Su, Takanari Inoue, Yu-Chun Lin*. Rapidly rewriting tubulin codes inside primary cilia. International Conference on Stem cells and developmental biology. Taipei, Taiwan,2015/10/16-2015/10/17	Yu-Chun Lin
2015	2015/06/28 2015/07/01	,2015,Emily Su, Takanari Inoue, Yu-Chun Lin*. Rapidly rewriting tubulin codes inside primary cilia. New Biological Frontiers Illuminated by Molecular Sensors and Actuators Meeting. Taipei, Taiwan,2015/06/28-2015/07/01 (其他)	Yu-Chun Lin
2015	0000/00/00 0000/00/00	Lin YC, Inoue T. Developing a method to achieve spatio-temporal loss-off-function inside primary cilium. The meeting series in the Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, U.S.A., (其他)	Yu-Chun Lin
2015	0000/00/00 0000/00/00	Lin YC. Manipulating molecular composition and activities in primary cilia by chemical biology approaches. The annual retreat in the Institute of Molecular Medicine, National Tsing Hua University, Taiwan. ,	Yu-Chun Lin
2015	0000/00/00 0000/00/00	Lin YC. Visualizing and manipulating molecular composition and activities in primary cilia by chemical biology approaches. The departmental seminar series in the College of Life Science, National Tsing Hua University, Taiwan. , (其他)	Yu-Chun Lin
2014	0000/00/00 0000/00/00	Lin YC, Inoue T. Chemically inducible cilia disintegration: a novel tool to study the specific roles of primary cilia. The meeting series in the Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, U.S.A.,	Yu-Chun Lin
2013	0000/00/00 0000/00/00	Lin YC, Lin B, Inoue T. Chemically inducible diffusion trap at cilia reveals molecular sieve-like barrier. The meeting series in the Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, U.S.A. ,	Yu-Chun Lin
2013	0000/00/00 0000/00/00	Lin YC, Inoue T. A new method for manipulating signaling proteins within the cilium using molecular traps. The American Society of Cell Biology 52th Annual Meeting, New Orleans, U.S.A. , (其他)	Yu-Chun Lin
2011	0000/00/00 0000/00/00	Lee, F.J.S., Lin, Y.C., Chiang, T.C., Liu, Y.T., Tsai, Y.T., Jang, L.T. (2011). ARL4A acts with GCC185 and CLASPs to modulate Golgi-derived microtubules and Golgi organization. The American Society of Cell Biology 51th Annual Meeting. Denver, U.S.A., (其他)	Yu-Chun Lin
2010	0000/00/00 0000/00/00	Lin, Y.C., Chiang, T.C., Liu, Y.T., Tsai, Y.T., Jang, L.T., Lee, F.J.S. (2010). ARL4A and GCC185 cooperate in regulating Golgi structure and endosome-to-Golgi transport. The American Society of Cell Biology 50th Annual Meeting. Pennsylvania, U.S.A., (其他)	Yu-Chun Lin
2008	0000/00/00 0000/00/00	Lin, Y.C., Hsu, W.C., Lo, H.F., Yang, V.C. (2008). The relationships between caveolin-1 and ABCA1 on the HDL-mediated cholesterol efflux in aortic endothelial cells. The 16th Symposium on Recent Advances in Cellular and Molecular Biology. Ken Ting, Taiwan, (其他)	Yu-Chun Lin
2008	0000/00/00 0000/00/00	Lin, Y.C., Hsu, W.C., Lo, H.F., Yang, V.C. (2008). The Relationships between Caveolin-1 and ABCA1 during the Cellular Cholesterol Efflux in Aortic Endothelial Cells. The 3rd NTU-Kyoto U student Mini-Symposium on Molecular and Cell Biology. Kyoto, Japan., (其他)	Yu-Chun Lin
2007	0000/00/00 0000/00/00	Lin, Y.C., Yang, V.C. (2007). Downregulation of ABCA1 reduces oligomerization and blocks Golgi exit of caveolin-1 in aortic endothelial cells. The American Society of Cell Biology 47th Annual Meeting. Washington D.C., U.S.A., (其他)	Yu-Chun Lin
2006	0000/00/00 0000/00/00	Lin, Y.C., Hsu, W.C., Lo, H.F., Yang, V.C. (2006). Interaction of caveolin-1 and ATP-Binding Cassette Transporter A1 on Cholesterol efflux. The American Society of Cell Biology 46th Annual Meeting, San Diego, U.S.A., (其他)	Yu-Chun Lin
2005	0000/00/00 0000/00/00	Lin, Y.C., Lin, W.W., Yang, V.C. (2005). Roles of caveolin-1 and ABCA1 on cholesterol efflux in rat aortic endothelial cells. The American Society of Cell Biology 45th Annual Meeting, San Francisco, U.S.A., (其他)	Yu-Chun Lin
2004	0000/00/00 0000/00/00	Chao, W.T., Tsai, S.H., Lin, Y.C., Yang, V.C. (2004). Cellular localization and interaction of HDL, caveolin-1, and ABCA1 in cholesterol-loaded aortic endothelial cells. The American Society of Cell Biology 44th Annual Meeting. Washington D.C., USA., (其他)	Yu-Chun Lin

Research Interests
Title	Date	Attached file
	2015-10-25	File download

Research Projects
Year	Project name	Participant	Assignment	Project period	Subsidized / Entrusted organization	Attached file/Reference link
108		Yu-Chun Lin		2019-02 ~ 2024-01		/
108		Yu-Chun Lin		2019-08 ~ 2021-07		/
107		Yu-Chun Lin		2018-08 ~ 2021-07		/
107		Yu-Chun Lin		2018-06 ~ 2019-12		/
106		Yu-Chun Lin		2016-08 ~ 2020-01		/
105		Yu-Chun Lin		2016-08 ~ 2019-07		/
104	Using chemical biology approaches to study the roles of tubulin post-translational modifications in primary cilia	Yu-Chun Lin	Principal investigator	2015-05 ~ 2016-07	Ministry of Science and Technology	/

Honors & Awards (NTHU)
Year of award	Name of award	Awarded by
109
107
107
106
106	Outstanding research award for junior faculty, College of Life Science, NTHU	College of Life Science, NTHU
106	Outstanding teaching award, College of Life Science, NTHU	College of Life Science, NTHU
105	Cash reward for outstanding teaching, College of Life Science, NTHU	College of Life Science, NTHU

Honors & Awards (outside NTHU)
Year of award	Name of award	Awarded by
109
108
107
106
105
104	科技部補助延攬特殊優秀人才	Ministry of Technology and Science
102	Travel award for American Society of Cell Biology 50th Annual Meeting, Johns Hopkins University School of Medicine	Johns Hopkins University School of Medicine
101	Postdoctoral fellowship for research abroad, National Science Council (awarded for 2 years)	National Science Council
97	The 3rd NTU-Kyoto U student Mini-Symposium on Molecular and Cell Biology, Outstanding poster design and presentation, Kyoto, Japan.	Kyoto University
97	The 16th Symposium on Recent Advances in Cellular and Molecular Biology, Excellent Poster Award, Taiwan.	The Society of cellular and molecular biology
96	Travel Award for Research Assistant, Graduate Student and Postdocs Taiwan.	Chinese Society of Cell and Molecular Biology
95	The Phi Tau Phi Scholastic Honor Society of the Republic of China	The Phi Tau Phi Society

Educational background summary
School name	Country	Department	Degree	Starting date
Tunghai University	Taiwan	Department of Life Science	Ph.D.	2004-08 ~ 2008-07
Tunghai University	Taiwan	Department of Life Science	Master degree student	2003-08 ~ 2004-07
Thughai University	Taiwan	Department of Life Science	B.S.	1999-08 ~ 2003-07

Experiences
Service organization/unit	Title	Department	Responsbilities	Starting date
National Tsing Hua University	Associate Professor	Institute of Molecular Medicine		2019-08 ~
National Tsing Hua University		Institute of Molecular Medicine	Assistant Professor	2015-02 ~ 2019-07
Johns Hopkins University School of Medicine		Department of Cell BIology	Research Fellow	2011-08 ~ 2015-01
National Taiwan University		Institute of Molecular Medicine		2009-07 ~ 2011-08
National Defense University		Chung Cheng Institute of Technology	Military Service	2008-07 ~ 2009-06

Subject

必修
1. 醫學科學導論　
2. 基礎生命科學實驗　
3. 分醫所書報討論　
4. 醫學科學實驗　
選修
1. 初級纖毛特論　
2. 合成生物學　
3. 高等細胞生物學

國立清華大學生命科學院分子醫學研究所

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國立清華大學生命科學院分子醫學研究所