Thy-Hou LinPersonal data of - 國立清華大學生命科學院分子醫學研究所

Faculty & Staff

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Name	Thy-Hou Lin
Personal website	http://life.nthu.edu.tw/~lslth/

Category	Retired
Title	Professor
Administrative Affairs	Institute of Molecular Medicine / The Department of Life Sciences / Interdisciplinary Program of Life Science
Discipline	Probiotics/Computer-aided drug design
Research expertise	Probiotics/Computer-aided drug design

Recent Publications
Year	Publication	Author
2011	Chiu, S.H., Chen, C.C., Yuan, G.F. and Lin, T.H.,2011,Deriving the Phylogenetic Information from Some Physicochemical Properties of Protein Sequences Computed, Journal of Computational Chemistry*,32,1,pp70-80 (SCI)	Thy-Hou Lin
2010	Lin, Y.R., Wei, H.Y., Tsai, T.L. and Lin, T.H.,2010,HDAPD: a web tool for searching the disease-associated protein structures,BMC Bioinformatics*,11,pp88- (SCI)	Thy-Hou Lin
2010	Chen, S.Y. and Lin, T.H.,2010,A molecular dynamics study on binding recognition between several 4,5 and 4,6-linked aminoglycosides with A-site RNA, Journal of Molecular Recognition*,23,5,pp423-434 (SCI)	Thy-Hou Lin
2009	Tsai, Y.K., Chen, H.W., Lo, T.C. and Lin, T.H.,2009,Specific point mutations in Lactobacillus casei ATCC 27139 cause a phenotype switch from Lac(-) to Lac(+),Microbiology-Sgm*,155,pp751-760 (SCI)	Thy-Hou Lin
2008	Chiu, S.H., Chen, C.C. and Lin, T.H.,2008,Using support vector regression to model the correlation between the clinical metastases time and gene expression profile for breast cancer,Artificial Intelligence in Medicine*,44,3,pp221-231 (SCI)	Thy-Hou Lin
2008	Lin, T.H.* and Lin, G.L. ,2008,An anchor-dependent molecular docking process for docking small flexible molecules into rigid protein receptors,Journal of Chemical Information and Modeling,48,8,pp1638-1655 (SCI)	Thy-Hou Lin
2008	Lo, T.C., Chen, H.W., Tsai, Y.K., Kuo, Y.C., Lin, C.F., Kuo, S.Y. and Lin, T.H.* ,2008,Formation of inverted repeat junction in the transposition of insertion sequence ISLC3 isolated from Lactobacillus casei,Microbiology,154,pp1047-1058 (SCI)	Thy-Hou Lin
2008	Wei, H.Y., Lu, C.S. and Lin, T.H.* ,2008,Exploring the P2 and P3 ligand binding features for Hepatitis C virus NS3 protease using some 3D QSAR techniques,Journal of Molecular Graphics & Modelling,26,7,pp1131-1144 (SCI)	Thy-Hou Lin
2006	Ke, Y.Y., Chen, Y.C. and Lin, T.H.,2006,Structure of the virus capsid protein VP1 of Enterovirus 71 predicted by some homology modeling and molecular docking studies, Journal of Computational Chemistry*,27,13,pp1556-1570 (SCI)	Thy-Hou Lin
2006	Lin, T.H., Chiu, S.H. and Tsai, K.C,2006,Supervised feature ranking using a genetic algorithm optimized artificial neural network,Journal of Chemical Information and Modeling*,46,4,pp1604-1614 (SCI)	Thy-Hou Lin
2006	Ke, Y.Y. and Lin, T.H.* ,2006,Modeling the ligand-receptor interaction for a series of inhibitors of the capsid protein of Enterovirus 71 using several three-dimensional quantitative structure-activity relationship techniques,Journal of Medicinal Chemistry ,49,15,pp4517-4525 (SCI)	Thy-Hou Lin
2006	Chiu, S.H., Chen, C.C., Yuan, G.F. and Lin, T.H.,2006,Association algorithm to mine the rules that govern enzyme definition and to classify protein sequences,BMC Bioinformatics*,7,pp7- (SCI)	Thy-Hou Lin
2006	Tsai, K.C., Chen, S.Y., Liang, P.H., Lu, I.L., Mahindroo, N., Hsieh, H.P., Chao, Y.S., Liu, L., Liu, D., Lien, W., Lin, T.H.* and Wu, S.Y.,2006,Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies,Journal of Medicinal Chemistry,49,12,pp3485-3495 (SCI)	Thy-Hou Lin
2006	Tsai, Y.K. and Lin, T.H.,2006,Sequence, organization, transcription and regulation of lactose and galactose operon in Lactobacillus rhamnosus TCELL-1,Journal of Applied Microbiology*,100,3,pp446-459 (SCI)	Thy-Hou Lin
2005	2005,Wei,H.Y., Tsai,K.C. and Lin*,T.H. Modeling ligand-receptor interaction for some MHC class II HLA-DR4 peptide mimetic inhibitors using several molecular docking and 3D QSAR techniques. Journal of Chemical Information and Modeling 45, 1343-1351 (2005). ,	Thy-Hou Lin
2005	2005,Lo,T.C., Shih,T.C., Lin,C.F., Chen,H.W. and Lin*,T.H. Complete genomic sequence of the temperate bacteriophage ΦAT3 isolated from Lactobacillus casei ATCC 393. Virology 339, 42-55 (2005). ,	Thy-Hou Lin
2005	2005,Chen,S.Y. and Lin*,T.H. A molecular dynamics study on the interaction of mithramycin dimer with a decanucleotide duplex. Journal of Physical Chemistry B 109, 9764-9772 (2005). ,	Thy-Hou Lin
2005	2005,Ke,Y.Y. and Lin*,T.H. A theoretical study on the activation of Ser70 in the acylation mechanism of cephalosporin antibiotics. Biophysical Chemistry 114, 103-113 (2005). ,	Thy-Hou Lin
2004	2005,Lin*,T.H., Li,H.T. and Tsai,K.C. Implementing the Fisher's discriminant ratio in a k-means clustering algorithm for feature selection and data set trimming. Journal of Chemical Information and Computer Science 44, 76-87 (2004). ,	Thy-Hou Lin
2004	2004,Tsai,K.C. and Lin*,T.H. A ligand-based molecular modeling study on some matrix metalloproteinase-1 inhibitors using several 3D QSAR techniques. Journal of Chemical Information and Computer Science 44, 1857-1871 (2004). ,	Thy-Hou Lin
2003	2003,Lin*,T.H., Tsai,K.C. and Lo,T.C. Homology modeling of the central catalytic domain of insertion sequence ISLC3 isolated from Lactobacillus casei ATCC 393. Protein Engineering 16, 819-829 (2003). ,	Thy-Hou Lin
2002	2002,Lin*,T.H., Wang,G.M. and Hsu,Y.H. Classification of some active HIV-1 protease inhibitors and their inactive analogues using some uncorrelated three-dimensional molecular descriptors and a fuzzy c-means algorithm. Journal of Chemical Information and Computer Science 42, 1490-1504 (2002). ,	Thy-Hou Lin
2002	2002,Lin*,T.H., Wang,G.M. and Wang,Y.T. Prediction of beta-turns in proteins using the first order Markov models. Journal of Chemical Information and Computer Science 42, 123-133 (2002). ,	Thy-Hou Lin
2002	2002,Peng,W.J., Chang,C.M. and Lin*,T.H. Target integration by a chimeric Sp1 zinc finger domain/Moloney murine leukemia virus integrase in vivo. Journal of Biomedical Science 9, 171-184 (2002). ,	Thy-Hou Lin
2001	2001,Lin*,T.H. and Lin,J.H. Three-dimensional quantitative structure-activity relationship for several bioactive peptides searched by a convex hull-CoMFA approach. Computers and Chemistry 25, 489-498 (2001). ,	Thy-Hou Lin
2000	2000,Lin*,T.H., Yu,Y.S. and Chen,H.J. Classification of some active compounds and their inactive analogues using two three-dimensional molecular descriptors derived from computation of three-dimensional convex hulls for structures theoretically generated for them. Journal of Chemical Information and Computer Science 40, 1210-1221 (2000). ,	Thy-Hou Lin
1999	1999,Lin*,T.H., Lin,J.J., Huang,Y.F. and Liu,J.H. Clustering peptide structures through identification of commonly exposed groups. Jouranl of Chemical Information and Computer Science 39, 622-629 (1999). ,	Thy-Hou Lin
1999	1999,Lin*,T.H., Lin,J.J., Peng,W.J. and Liu,J.H. Common structural folds in several protein pairs searched by an iterative superposition algorithm. Computers and Chemistry 23, 109-119 (1999). ,	Thy-Hou Lin
1999	1999,Lin*,T.H., Lin,J.J. and Lu,Y.J. A comparative molecular field analysis study on several bioactive peptides using the alignment rules derived from identification of commonly exposed groups. Biochimica et Biophisica Acta 1429, 476-485 (1999). ,	Thy-Hou Lin
1998	1998,Lin*,T.H., Peng,W.J. and Lu,Y.J. Identification of convexity as a common structure feature for structures generated for two short peptides. Computers and Chemistry 22, 309-320 (1998). ,	Thy-Hou Lin
1997	1997,Peng,W.J., Pan,J.T., Lai,M.C., Chiu,C.F. and Lin*,T.H. The genome of Moloney murine leukemia virus can be integrated by the integrase of human immunoideficiency virus type 1 expressed alone in vivo. Proceeding of National Science Council Part B: Life Sci. 21, 144-160 (1997). ,	Thy-Hou Lin
1997	1997,Lin*,T.H., Peng,W.J. and Lin,J.J. A contact scoring matrix for qualitative prediction of packing of alpha-helix in globular proteins. Biochimica et Biophyisica Acta 1337, 17-26 (1997). ,	Thy-Hou Lin
1996	1996,Lin*,T.H., Pan,J.T. and Peng,W.J. A novel charge distribution method for the numerical solution of the Poisson-Boltzmann equation. Journal of Chinese Chemical Society 43, 7-16 (1996). ,	Thy-Hou Lin
1996	1996,Cheng,J.W., Cheng,C.C., Lyu,P.C., Chen,S.T. and Lin,T.H. Solution conformation of a peptide corresponding to residues 151-172 of HIV-1 integrase using NMR and CD spectroscopy. International J.ournal of Peptide Protein Research 47, 117-122 (1996). ,	Thy-Hou Lin
1994	1994,Wang,C.Y., Yang,C.F., Lai,M.C., Lee,Y.H., Lee,T.L. and Lin*,T.H. Molecular dynamics simulations of a leucine zipper motif predicted for the integrase of human immunodeficiency virus type 1. Biopolymers 34, 1027-1036 (1994). ,	Thy-Hou Lin
1991	1991,Lin,T.H., Quinn,T., Walsh,M., Grandgenett,D.P. and Lee,J. Avian myeloblastosis virus reverse transcriptase: effect of gylcerol on its hydrodynamic properties. Journal of Biological Chemistry 266, 1635-1640(1991). ,	Thy-Hou Lin
1991	1991,Lin,T.H. and Grandgenett,D.P. Retrovirus integrase: Identification of a potential leucine zipper. Protein Engineering 4, 435-441 (1991). ,	Thy-Hou Lin
1991	1991,Buxbaum,R,E., Yam,K.L., Lin,T.H. and Phillies,G.D.J. A local viscosity model for the diffusion of spherical particles in polymer containing solution. AIChE J. 37, 654-659 (1991). ,	Thy-Hou Lin
1989	1989,Lin,T.H., Quinn,T.P., Walsh,M.T. and Grandgenett,D.P. Secondary structural analysis of retrovirus integrase: Characterization by circular dichroism and empirical prediction methods. Proteins Structure Function and Genetics 5, 156-165 (1989). ,	Thy-Hou Lin
1988	1988,Lin,T.H., Leed,H.A., Scheraga,H.A. and Mattice,W.L. Helix destabilization caused by the interaction of unaggregated sodium dodecyl sulfate with isolated lysine residues. Macromolecules 21, 2447-2452 (1988). ,	Thy-Hou Lin
1988	1988,Lin,T.H., Leed,H.A., Scheraga,H.A. and Mattice,W.L. Helix initiation and propagation by isolated arginine residues in aqueous sodium dodecyl sulfate. Macromolecules 21, 131-136(1988). ,	Thy-Hou Lin
1986	1986, Lin,T.H.,Cherry,W.R. and Mattice,W.L. Acridine fluorescence as a probe of micelle formation by sodium dodecyl sulfate in the presence of poly(hydroxyalkyl-L-glutamine). Polymer Communication 27, 37-38 (1986). ,	Thy-Hou Lin
1986	1986,Lin*,T.H. Diffusion of TiO2 probe particles through a poly(ethylene oxide) melt. Makromoleluar Chemistry 187, 1189-1196 (1986). ,	Thy-Hou Lin
1985	1985,Phillies,G.D.J.,Ullman,G.S.,Ullman,K. and Lin,T.H. Phenomenological scaling laws for semi-dilute macromolecular solutions from light scattering by optical probe particles. Journal of Chemical Physics 82, 5242-5246 (1985). ,	Thy-Hou Lin
1984	1984,Lin,T.H. and Phillies,G.D.J. Polymer molecular weight and probe diffusion in water:poly(acrylic) acid solutions. Journal of Colloid Interface Science 100, 82-95 (1984). ,	Thy-Hou Lin
1984	1984,Lin,T.H. and Phillies,G.D.J. Probe size and restricted diffusion in water:poly(acrylic) acid solutions. Macromolecules 17, 1686-1691 (1984). ,	Thy-Hou Lin
1982	1982,Lin,T.H. and Phillies,G.D.J. Translational diffusion of macroparticulate probes in a polymer-containing solvent. Journal of Physical Chemistry 86, 4073-4077 (1982). ,	Thy-Hou Lin

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